bs-82985C

DATASHEET

Formulation White solid

Storage: -20°C

Product Information:

Potent (IC50 = 27 nM) inhibitor of the TAM family kinase AXL.1 It displayed potent activity against the pancreatic tumor cell line PSN-1 (IC50 = 6 nM). Dubermatinib also strongly inhibited the kinases Aurora A/B, JAK2, ABL1, and CHEK1. It induced apoptosis in chronic lymphocytic leukemia (CLL) cells and acted synergistically with BTK inhibitors against CLL cells.2 It inhibited neuroblastoma cell growth and enhanced sensitivity to conventional chemotherapy.3 Dubermatinib was also active in a drug-resistant acute myeloid leukemia model4 and reduced metastasis and therapy resistance in pancreatic cancer models5.

Description:

CAS Number: 1341200-45-0 Chemical Name: 2-[[5-Chloro-2-[4-[(4-methylpiperazine-1-yl)methyl]pyrimidine-4-yl]amino]-N,N-dimethylbenzenesulfonamide Molecular weight: 516.06 Formula: C24H30ClN7O2S Solubility: DMSO (>25 mg/ml) Physical Properties: White solid Purity: 98% by HPLC NMR (Conforms)