bs-82989C

DATASHEET

Formulation Off-White solid

Storage: -20°C

Product Information:

BO-264 is a potent (IC50 = 188 nM) inhibitor of transforming acidic coiled-coil 3 (TACC3), an important protein involved in microtubule stability and centrosome integrity.1 TACC3 is frequently upregulated in a broad range of cancers. BO-264 displayed significant anticancer activity in greater than 90% of cell lines in the NCI-60 human cancer cell line panel. Active in vivo in mice injected with JIMT-1 and EMT6 breast cancer cells as well as mouse colon cancer xenografts HCT-116 and CT-26.

Description:

CAS Number: 2408648-20-2; Chemical Name: 3-(4-Methoxyphenyl)-N-(2-morpholin-4-ylpyrimidin-4-yl)-1,2-oxazol-5-amine; Molecular weight: 353.38; Formula: C18H19N5O3; Solubility: DMSO (>25 mg/ml); Physical Properties: Off-white solid; Purity: 99% by HPLC NMR (Conforms)

Size: 5mg, 25mg

Applications: Life Science(N/A)

For research use only. Not intended for diagnostic or therapeutic use.