bs-83010C

DATASHEET

Formulation Orange-yellow solid

Storage: -20°C

Product Information:

LDN-193189 HCl is a potent and selective inhibitor of ALK2 (IC50 = 5 nM) and ALK3 (IC50 = 30 nM), thereby inhibiting SMAD1/5/8 phosphorylation.1 Only weak inhibition of ALK4, ALK5, and ALK7 is observed. Promotes neuronal differentiation of human pluripotent stem cells.2-3 LDN-193189 HCl has also been used to examine the role of osteogenesis in prostate tumor metastases in bone.4

Description:

CAS Number: 1062368-62-0; Chemical Name: 4-[6-[4-(1-Piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]-quinoline hydrochloride; Molecular weight: 479.4; Formula: C25H22N6·2HCl; Solubility: DMSO or Water (up to 5 mg/ml); Physical Properties: Orange-yellow solid; Purity: 99% by HPLC (Agilent Poroshell 120 C18, 80/20 MeOH/water with 0.05% TFA; 0.8 ml/min) NMR (Conforms)

Size: 5mg, 25mg

Applications: Life Science(N/A)

For research use only. Not intended for diagnostic or therapeutic use.