bs-83025C

DATASHEET

Formulation yellow solid

Storage: -20°C

Product Information:

MK-2206 is a potent and selective allosteric inhibitor of Akt (IC50’s: Akt1 = 5 nM, Akt2 = 12 nM, Akt3 = 65 nM) that enhances the in vitro and in vivo antitumor efficacy of several standard chemotherapeutic agents.1 It was able to decrease insulin-stimulated glucose uptake, glycogen synthesis and glycogen synthase activity in rat muscle.2 MK-2206 induced G1-phase cycle arrest and sensitized HepG2 hepatocellular carcinoma cells to TRAIL-induced apoptosis.3

Description:

CAS Number: 1032350-13-2; Chemical Name: 8-(4-(1-Aminocyclobutyl)phenyl-9-phenyl-2H-[1,2,4]triazolo[3,4-f][1,6]naphthyridin-3-one dihydrochloride; Molecular weight: 480.39; Formula: C25H21N5O·2HCl; Solubility: DMSO (10 mg/ml); Physical Properties: Yellow solid; Purity: 98% by HPLC, NMR (Conforms)

Size: 5mg, 25mg

Applications: Life Science(N/A)

For research use only. Not intended for diagnostic or therapeutic use.