DATASHEET
Formulation
Off-white to beige solid
Storage:
-20°C
Product Information:
NU7441 is a potent (IC50 = 13 nM) and selective ATP-competitive inhibitor of DNA-dependent protein kinase (DNA-PK).1,2 It increased the toxicity of ionizing radiation and etoposide on SW620 human colon cancer lines via impeding of DNA double-strand break repair.3 NU7441 also increased the radio/chemosensitivity of various other cancer cell lines.3-6
Description:
CAS Number: 503468-95-9; Chemical Name: 8-Dibenzothiophen-4-yl-2-morpholin-4-ylchromen-4-one; Molecular weight: 413.49; Formula: C25H19NO3S; Solubility: DMSO (10 mg/ml); Physical Properties: Off-white to beige solid; Purity: 98% by TLC NMR (Conforms)