DATASHEET
Formulation
yellow solid
Storage:
-20°C
Product Information:
LDN-192960 is a potent inhibitor of Haspin (IC50 = 10 nM), DYRK2 (IC50 = 2 nM), and DYRK3 (IC50 = 19 nM).1,2 It induced cytotoxicity and growth inhibition in multiple myeloma and triple negative breast cancer cells and triple negative breast cancer mouse allo/xenografts via partial inhibition of 26S proteasome activity.3
Description:
CAS Number: 184582-62-5; Chemical Name: 3-(2,7-Dimethoxyacridin-9-yl)sulfanylpropan-1-amine dihydrochloride; Molecular weight: 401.35; Formula: C18H20N2O2S·2HCl; Solubility: DMSO (>25 mg/ml) Water (2 mg/ml); Physical Properties: Yellow solid; Purity: >98% by HPLC NMR (Conforms)