bs-83054C

DATASHEET

Formulation white or off-white solid

Storage: -20°C

Product Information:

Selectively induces apoptosis in cells with truncations in the adenomatous polyposis coli (APC) gene (but not normal cells or wild type cancer cells), an important multifunctional tumor suppressor gene.1 IC50 = 70nM for DLD1 cell line. It inhibited cancer cell growth in human tumor xenografts (DLD1 and HT29 tumors) and a genetically engineered mouse model (CPC;Apc) of colorectal cancer. TASIN-1 induces ER stress-dependent JNK activation with ROS production and AKT inhibition via cholesterol depletion.2

Description:

CAS Number: 1678515-13-3; Chemical Name: 1-[1-(4-Methoxyphenyl)sulfonylpiperidin-4-yl]-4-methylpiperidine hydrochloride; Molecular weight: 388.95; Formula: C18H28N2O3S·HCl; Solubility: DMSO (20 mg/ml); Physical Properties: White or off-white solid; Purity: 98% by HPLC NMR (Conforms)

Size: 5mg, 25mg

Applications: Life Science(N/A)

For research use only. Not intended for diagnostic or therapeutic use.