bs-83099C
[Life Science]
C-DIM 8
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support@biossusa.com
800.501.7654 [DOMESTIC]
+1.781.569.5821 [INTERNATIONAL]
DATASHEET
Formulation Pink solid
Storage: -20°C
Product Information:
C-DIM 8 is an antagonist of the orphan nuclear receptor Nur77 (NR4A1, TR3).1 Induces reactive oxygen species and ER stress in pancreatic cancer cells.2 C-DIM 8 mimics the effect of Nur77 knockdown in non-small-cell lung cancer A549 and H460 cells, inhibiting cell growth and inducing apoptosis which was accompanied by decreased expression of survivin and inhibition of mTORC1 signaling.3 Inhibits the expression of β1- and β3-integrin and blocks integrin-dependent breast cancer cell migration.4 Decreases expression of the histone methyltransferase G9A (EHMT2) in a variety of cancer cell lines.5
Description:
CAS Number: 151358-47-3<br></br>Chemical Name: 1,1-Bis(3’-indolyl)-1-(p-hydroxyphenyl)methane<br></br>Molecular weight: 338.41<br></br>Formula: C23H18N2O<br></br>Solubility: DMSO (35 mg/ml) Ethanol (35 mg/ml)<br></br>Physical Properties: Pink solid<br></br>Purity: 98% by TLC, NMR (Conforms)
Size: 5mg, 25mg
Applications: Life Science
For research use only. Not intended for diagnostic or therapeutic use.