bs-83108C
[Life Science]
RECTAS
www.biossusa.com
support@biossusa.com
800.501.7654 [DOMESTIC]
+1.781.569.5821 [INTERNATIONAL]
support@biossusa.com
800.501.7654 [DOMESTIC]
+1.781.569.5821 [INTERNATIONAL]
DATASHEET
Formulation Pale yellow solid
Storage: -20°C
Product Information:
RECTAS, a pre-mRNA splice modulator (Rectifier of Aberrant Splicing), was discovered in a small molecule screen for compounds that rectify aberrant IKBKAP splicing in cells from patients with familial dysautonomia. RECTAS (2 mM) increased the expression of IKAP and restored tRNA modifications.1,2 It directly interacts with CDC-like kinases enhancing SRSF6 phosphorylation.2 A combination treatment with RECTAS and phenylbutyric acid was shown to restore DJ-1 protein and mitochondrial dysfunction in Parkinson’s disease models.3
Description:
CAS Number: 101862-47-9<br></br>Chemical Name: 2-Chloro-N-(2-furanylmethyl)-9H-purin-6-amine<br></br>Molecular weight: 249.66<br></br>Formula: C10H8ClN5O<br></br>Solubility: DMSO (27 mg/ml)<br></br>Physical Properties: Pale yellow solid<br></br>Purity: >98% by TLC NMR (Conforms)
Size: 5mg, 25mg
Applications: Life Science
For research use only. Not intended for diagnostic or therapeutic use.