bs-83136C
[Life Science]
Ketoconazole (base)
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support@biossusa.com
800.501.7654 [DOMESTIC]
+1.781.569.5821 [INTERNATIONAL]
DATASHEET
Formulation Off-white solid
Storage: RT
Product Information:
Ketoconazole is a broad spectrum antifungal agent which acts via inhibition of a cytochrome P450, CYP51A1 which is a lanosterol 14-demethylase.1 Also inhibits CYP3A and CYP1A1.2 Inhibits adrenal steroidogenesis.3 Downregulates cholesterol synthesis in drug-tolerant human lung cancer cell lines.4 Blocks the biosynthesis of leukotrienes (LT) via inhibition of 5-lipoxygenase and dose dependently inhibits LT-mediated bronchoconstriction in guinea pigs.5
Description:
CAS Number: 65277-42-1<br></br>Chemical Name: Cytochrome P450 inhibitor<br></br>Molecular Weight: 531.43<br></br>Formula: C26H28Cl2N4O4<br></br>Solubility: DMSO (25 mg/ml); Ethanol (20 mg/ml)<br></br>Physical Properties: Off-white solid<br></br>Purity: >98% by TLC
Size: 100mg, 500mg
Applications: Life Science
For research use only. Not intended for diagnostic or therapeutic use.