bs-83160C [Life Science]
Necrostatin-1
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Formulation Pale yellow solid

Storage: RT

Product Information:

Necrostatin-1 is an inhibitor of necroptosis (non-apoptotic cell death pathway; EC50 = 494 nM).1 It is an ATP-competitive death domain receptor-associated adaptor kinase (RIP1) inhibitor (EC50 = 182 nM).2 It displays a protective effect in a mouse model of ischemic brain injury1, inhibits myocardial cell death and reduces infarct size in various mouse heart models3 and inhibits glutamate-induced oxytosis in HT-22 cells4.

Description:

CAS Number: 4311-88-0<br></br>Chemical Name: Necroptosis inhibitor<br></br>Molecular Weight: 259.33<br></br>Formula: C13H13N3OS<br></br>Solubility: DMSO (20 mg/ml) Ethanol (5 mg/ml)<br></br>Physical Properties: Pale yellow solid<br></br>Purity: 98% by TLC [5% methanol in methylene chloride, Rf = 0.37] NMR Conforms

Size: 50mg, 10mg

Applications: Life Science

For research use only. Not intended for diagnostic or therapeutic use.