bs-83219C
[Life Science]
NSC47924
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support@biossusa.com
800.501.7654 [DOMESTIC]
+1.781.569.5821 [INTERNATIONAL]
DATASHEET
Formulation Yellow solid
Storage: -20°C
Product Information:
A potent inhibitor of the Leucine-rich repeat protein phosphatase (PHLPP) an enzyme which is a negative regulator of Akt and PKC (IC50=4 M).1 Increases AKT signaling in cells and prevents apoptosis. Also inhibits the 67 kDa laminin receptor (LR) interaction with laminin (LM) and selectively blocks LR-293 cell adhesion to LM IC50=19.35 M) impairing cell migration and invasion.2 Affects 37/67 kDa LR cell surface localization and interaction with cellular prion protein.3
Description:
CAS Number: 6638-24-0<br></br>Chemical Name: PHLP phosphatase inhibitor / Laminin inhibitor<br></br>Molecular Weight: 279.33<br></br>Formula: C18H17NO2<br></br>Solubility: DMSO (30 mg/ml) Ethanol (10 mg/ml)<br></br>Physical Properties: Yellow solid<br></br>Purity: 98% by TLC NMR (Conforms)
Size: 25mg, 5mg
Applications: Life Science
For research use only. Not intended for diagnostic or therapeutic use.