bs-83309C
[Life Science]
Topotecan HCl
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support@biossusa.com
800.501.7654 [DOMESTIC]
+1.781.569.5821 [INTERNATIONAL]
support@biossusa.com
800.501.7654 [DOMESTIC]
+1.781.569.5821 [INTERNATIONAL]
DATASHEET
Formulation Yellow solid
Storage: -20°C
Product Information:
Topotecan HCl is a water-soluble and orally active analog of camptothecin, a DNA topoisomerase I inhibitor.1 Inhibits topoisomerase I in human MCF-7 breast and DU-145 prostate cancer cells, IC50s = 13 and 2 nM respectively.2 Downregulates B-Myb and MycN expression in neuroblastoma cells.3 A clinically useful anticancer agent.
Description:
CAS Number: 119413-54-6<br></br>Chemical Name: DNA topoisomerase I inhibitor<br></br>Molecular Weight: 457.91<br></br>Formula: C23H23N3O5 • HCl<br></br>Solubility: DMSO (50 mg/ml); water (50 mg/ml)<br></br>Physical Properties: Yellow solid<br></br>Purity: >98% by HPLC NMR (Conforms)
Size: 50mg, 10mg
Applications: Life Science
For research use only. Not intended for diagnostic or therapeutic use.