bs-83340C

DATASHEET

Formulation Pale green solid

Storage: -20°C

Product Information:

Cyclin-dependent kinase inhibitor. IC50s= 4, 70, 35, 75 and 850 nM for cdc2/cyclin B, cdk2/cyclin A, cdk2/cyclin E, cdk5/p35 and cdk4/cyclin D1 and respectively.1 Reversibly arrests synchronized cells in G1 and G2 phase.2 Induces ER stress-mediated apoptosis and autophagy in colon cancer cells.3 Suppresses Src-mediated transformation by inhibiting both CDKs and c-Src.4 In cells transformed with MYC, purvalanol A rapidly down-regulates survivin expression and induces MYC-dependent apoptosis.5 Cell permeable.

Description:

CAS Number: 212844-53-6; Chemical Name: CDK inhibitor; Molecular Weight: 388.89; Formula: C19H25ClN6O; Solubility: DMSO (35 mg/ml); Physical Properties: Pale green solid; Purity: 98% by HPLC, NMR (Conforms)

Size: 25mg, 5mg

Applications: Life Science(N/A)

For research use only. Not intended for diagnostic or therapeutic use.