bs-83340C
[Life Science]
Purvalanol A
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support@biossusa.com
800.501.7654 [DOMESTIC]
+1.781.569.5821 [INTERNATIONAL]
DATASHEET
Formulation Pale green solid
Storage: -20°C
Product Information:
Cyclin-dependent kinase inhibitor. IC50s= 4, 70, 35, 75 and 850 nM for cdc2/cyclin B, cdk2/cyclin A, cdk2/cyclin E, cdk5/p35 and cdk4/cyclin D1 and respectively.1 Reversibly arrests synchronized cells in G1 and G2 phase.2 Induces ER stress-mediated apoptosis and autophagy in colon cancer cells.3 Suppresses Src-mediated transformation by inhibiting both CDKs and c-Src.4 In cells transformed with MYC, purvalanol A rapidly down-regulates survivin expression and induces MYC-dependent apoptosis.5 Cell permeable.
Description:
CAS Number: 212844-53-6<br></br>Chemical Name: CDK inhibitor<br></br>Molecular Weight: 388.89<br></br>Formula: C19H25ClN6O <br></br>Solubility: DMSO (35 mg/ml)<br></br>Physical Properties: Pale green solid<br></br>Purity: 98% by HPLC, NMR (Conforms)
Size: 25mg, 5mg
Applications: Life Science
For research use only. Not intended for diagnostic or therapeutic use.