DATASHEET
Formulation
White Solid
Storage:
-20°C
Product Information:
Reported to be an inhibitor of calcineurin (PP2B), IC50~100 pM1 but this activity has been disputed2. Markedly enhances the expression of BDNF in cultured rat cortical neurons and displays neurotrophic effects.3 Produces antidepressant-like effects in mice.4 Blocks the spontaneous down-regulation of Nav1.8 sodium channels expressed in Xenopus oocytes.5
Description:
CAS Number: 52918-63-5; Chemical Name: Calcineurin inhibitor; displays neurotrophic activity; Molecular Weight: 505.20; Formula: C22H19Br2NO3; Solubility: DMSO (50 mg/ml); Physical Properties: White solid; Purity: 98% by TLC and GC, NMR (Conforms)