DATASHEET
Formulation
White solid
Storage:
-20°C
Product Information:
Reported to be an inhibitor of calcineurin (PP2B), IC50~100 pM1 but this activity has been disputed2. Markedly enhances the expression of BDNF in cultured rat cortical neurons and displays neurotrophic effects.3 Produces antidepressant-like effects in mice.4 Blocks the spontaneous down-regulation of Nav1.8 sodium channels expressed in Xenopus oocytes.5
Description:
CAS Number: 52918-63-5<br></br>Chemical Name: Calcineurin inhibitor; displays neurotrophic activity<br></br>Molecular Weight: 505.20<br></br>Formula: C22H19Br2NO3 <br></br>Solubility: DMSO (50 mg/ml)<br></br>Physical Properties: White solid<br></br>Purity: 98% by TLC and GC, NMR (Conforms)