bs-83349C

DATASHEET

Formulation White Solid

Storage: -20°C

Product Information:

Novel inhibitor of c-met and VEGFR2 kinase activity, IC50=3.5 nm and 35 pM respectively.1 Inhibits MET-activating kinase domain mutations Y1248H, D1246N or K1262R, IC50=3.8, 11.8 and 14.6 nM respectively. In cellular assays it inhibits the following kinases: MET, VEGF2, KIT, FLT3 and AXL, IC50=7.8, 1.9, 5.0, 7.5 and 42 μM respectively.1 Eliminated approximately 80% of vasculature in spontaneous pancreatic islet tumors over 7 days in a mouse model.2 Clinically useful anticancer agent.3

Description:

CAS Number: 849217-68-1; Chemical Name: Met and VEGFR2 inhibitor; Molecular Weight: 501.51; Formula: C28H24FN3O5; Solubility: DMSO; Physical Properties: White solid; Purity: 98% by HPLC, NMR (Conforms)

Size: 25mg, 5mg

Applications: Life Science(N/A)

For research use only. Not intended for diagnostic or therapeutic use.