bs-83353C [Life Science]
Nintedanib
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Formulation Yellow solid

Storage: -20°C

Product Information:

Nintedanib is a potent inhibitor of VEGFR, PDGFR, FGFR (IC50 = 13-34 nM for VEGFR, 59-65 nM for PDGFR and 37-108 nM for FGFR subtypes).1 Also inhibits Flt-3, Lck, Lyn and Src (IC50 = 16-156 nM). Inhibits VEGF-stimulated proliferation of HUVECs.1 Inhibits tumor growth in a mouse tumor xenograft model.1 A novel therapeutic agent for treatment of idiopathic pulmonary fibrosis.2,3 Alleviates chronic pancreatitis by inhibiting the activation of pancreatic stellate cells.4

Description:

CAS Number: 656247-17-5<br></br>Chemical Name: VEGFR, PDGFR and FGFR kinase inhibitor<br></br>Molecular Weight: 539.64<br></br>Formula: C31H33N5O4<br></br>Solubility: DMSO (4 mg/ml)<br></br>Physical Properties: Yellow solid<br></br>Purity: >98% by HPLC NMR (Conforms)

Size: 50mg,10mg

Applications: Life Science()

For research use only. Not intended for diagnostic or therapeutic use.