bs-83362C [Life Science]
Neratinib
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Formulation White solid

Storage: -20°C

Product Information:

Neratinib is a potent, irreversible inhibitor of HER2/ErbB2 receptor tyrosine kinase and EGFR kinase (IC50’s= 59 nM and 92 nM, respectively). It suppresses receptor autophosphorylation and proliferation, blocks cell-cycle progression and inhibits HER2 signaling in of EGFR-dependent cancer cells and tumor xenograft models.1 Neratinib inhibits proliferation of gefitinib-resistant non-small cell lung cancer cells expressing mutant EGFR.2 Synergizes with dasatinib in HER2-positive cancer cells and xenografts.3 It’s been shown to also inhibit MST1 (IC50 = 37.7 nM).4

Description:

CAS Number: 698387-09-6<br></br>Chemical Name: Dual EGFR and HER2 inhibitor<br></br>Molecular Weight: 557.05<br></br>Formula: C30H29ClN6O3<br></br>Solubility: DMSO (4 mg/ml, warm)<br></br>Physical Properties: White solid<br></br>Purity: >98% by HPLC NMR (Conforms)

Size: 100mg,20mg

Applications: Life Science()

For research use only. Not intended for diagnostic or therapeutic use.