bs-83376C
[Life Science]
AZD7648
www.biossusa.com
support@biossusa.com
800.501.7654 [DOMESTIC]
+1.781.569.5821 [INTERNATIONAL]
support@biossusa.com
800.501.7654 [DOMESTIC]
+1.781.569.5821 [INTERNATIONAL]
DATASHEET
Formulation White solid
Storage: -20°C
Product Information:
AZD7648 is a very potent and selective (against 397 kinases) DNA-PK inhibitor (pIC50 = 9.2; cellular pIC50 = 7.0).1 It is a sensitizer of radiation- and doxorubicin-induced DNA damage and sustained tumor regression in xenograft and patient-derived xenograft models.2 AZD7648 significantly enhances precise CRISPR/Cas9 gene editing alone3,4,5 or in combined treatment with a DNA polymerase theta inhibitor (2iHDR cocktail)5.
Description:
CAS Number: 2230820-11-6<br></br>Chemical Name: DNA-PK inhibitor/CRISPR enhancer<br></br>Molecular Weight: 380.41<br></br>Formula: C18H20N8O2<br></br>Solubility: DMSO (5 mg/ml with warming)<br></br>Physical Properties: White solid<br></br>Purity: >98% by HPLC NMR (Conforms)
Size: 25mg,5mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.