bs-83401C [Life Science]
AGI-5198
www.biossusa.com
support@biossusa.com
800.501.7654 [DOMESTIC]
+1.781.569.5821 [INTERNATIONAL]
DATASHEET

Formulation White solid

Storage: -20°C

Product Information:

AGI-5198 is a potent (IC50 = 70 nM) inhibitor of mutant isocitrate dehydrogenase 1(IDH1).1 It is selective for the R132H-IDH1 mutant and does not affect wild type cells.2 This mutation results in loss-of-function for oxidative decarboxylation of isocitrate and gain-of-function for production of the oncometabolite R-2-hydroxyglutarate (R-2HG) form alpha-ketoglutarate (2-OG).

Description:

CAS Number: 1355326-35-0<br></br>Chemical Name: R132 mutant isocitrate dehydrogenase inhibitor<br></br>Molecular Weight: 462.56<br></br>Formula: C27H31FN4O2 <br></br>Solubility: DMSO (10 mg/ml) Ethanol (5 mg/ml)<br></br>Physical Properties: White solid<br></br>Purity: 98% by HPLC, NMR (Conforms)

Size: 25mg,5mg

Applications: Life Science()

For research use only. Not intended for diagnostic or therapeutic use.