DATASHEET
Formulation
White Solid
Storage:
-20°C
Product Information:
Gimeracil is a dihydropyrimidine dehydrogenase (DPD) inhibitor. DPD is involved in the degradation of pyrimidine-based chemotherapeutic drugs such as 5-fluorouracil (5-FU). Gimeracil is used along with 5-FU or Tegafur to prolong circulating concentrations of the drugs.1,2 Gimeracil has also been shown to act as a radiosensitizer via inhibition of homologous recombination in the repair of DNA double strand breaks.3
Description:
CAS Number: 103766-25-2; Chemical Name: Dihydropyrimidine dehydrogenase inhibitor; Molecular Weight: 145.54; Formula: C5H4ClNO2; Solubility: DMSO (5 mg/ml); Physical Properties: White solid; Purity: 98% by HPLC, NMR (Conforms)