bs-83404C

DATASHEET

Formulation White Solid

Storage: -20°C

Product Information:

P505-15 is a highly selective and potent (IC50 = 1-2 nM) inhibitor of spleen tyrosine kinase (Syk).1 It potently inhibited B cell antigen receptor-mediated B cell signaling/activation and basophil degranulation. It displayed anti-inflammatory activity in rodent models of rheumatoid arthritis. P505-15 displayed efficacy in vitro and in vivo in non-Hodgkin lymphoma and chronic lymphocytic leukemia models.2,3 It protected against toxin-induced hepatic fibrosis, associated hepatocellular injury, and hepatocarcinogenesis.4 P505-15 was also found to inhibit PINK1 (IC50 = 0.5-3 µM) in HeLa cells and dopaminergic neurons.5

Description:

CAS Number: 1370261-97-4; Chemical Name: Highly selective Syk inhibitor; Molecular Weight: 429.91; Formula: C19H23N9O·HCl; Solubility: DMSO (25 mg/mL); Water (>25 mg/mL); Physical Properties: White solid; Purity: >98% by HPLC NMR (Conforms)

Size: 25mg, 5mg

Applications: Life Science(N/A)

For research use only. Not intended for diagnostic or therapeutic use.