bs-83405C

DATASHEET

Formulation White Solid

Storage: -20°C

Product Information:

Vorasidenib is a highly potent (IC50’s = 7 nM IDH2-R140Q, 0.6 nM IDH1-R132H/WT, and 0.25 nM Neurosphere TS603 IDH1-R132H), selective, and brain-penetrant inhibitor of mutant isocitrate dehydrogenase 1 and 2 (IDH1/2).1 It led to >97% inhibition of 2-hydroxyglutarate production in mIDH1 glioma tissue. Vorasidenib significantly improved progression-free survival and delayed time to next intervention in a phase 3 glioma trial.2

Description:

CAS Number: 1644545-52-7; Chemical Name: Isocitrate dehydrogenase (IDH) 1/2 inhibitor; Molecular Weight: 414.74; Formula: C14H13ClF6N6; Solubility: DMSO (25 mg/ml); Physical Properties: White solid; Purity: >98% by HPLC NMR (Conforms)

Size: 25mg, 5mg

Applications: Life Science(N/A)

For research use only. Not intended for diagnostic or therapeutic use.