bs-83408C

DATASHEET

Formulation White to off-white solid

Storage: -20°C

Product Information:

Rebastinib is a potent ABL1 kinase inhibitor (IC50 = 0.8 nM) that binds to amino acid residues that are used to switch between active and inactive conformations.1 It inhibits both phosphorylated and unphosphorylated ABL1 as well as gatekeeper mutant T315I (IC50 = 4 nM). Rebastinib was active against chronic myeloid leukemia Ba/F3 cells expressing BCR-ABL (IC50 = 19 nM) and BCR-ABLT315I (IC50 = 63 nM) and most kinase mutants.2 Rebastinib has been reported to inhibit the growth and metastasis of xenografted MDA-MB-231 triple-negative breast cancer cells by targeting AXL/MET.3 It has also been shown to be a potent inhibitor of Tie2 kinase (IC50 = 0.63 nM).4 Rebastinib blocked necroptosis via inhibition of RIPK1 and RIPK3.5

Description:

CAS Number: 1020172-07-9 Chemical Name: Bcl-Abl1 inhibitor Molecular Weight: 553.6 Formula: C30H28FN7O6 Solubility: DMSO (>25 mg/ml) Physical Properties: White to off-white solid Purity: >98% by HPLC NMR (Conforms)