bs-83411C
[Life Science]
Ibrutinib
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support@biossusa.com
800.501.7654 [DOMESTIC]
+1.781.569.5821 [INTERNATIONAL]
DATASHEET
Formulation White or off-white solid
Storage: -20°C
Product Information:
Ibrutinib (936563-96-1) is a very potent (IC50 = 0.5nM) irreversible inhibitor of Bruton tyrosine kinase (BTK) that blocks activation of the B-cell antigen receptor (BCR).1 Ibrutinib also potently inhibits several other kinases including BLK, BMS, FGR, EGFR, and ITK. It is a clinically useful drug to treat B cell cancers. It inhibits CLL cell migration and survival2,3 and downregulates expression of CD204. It enhanced antitumor immune responses in combination with anti PD-L1 blockade via its inhibition of ITK (IL2-inducible T-cell kinase).5
Description:
CAS Number: 936563-96-1<br></br>Chemical Name: BTK inhibitor<br></br>Molecular Weight: 440.51<br></br>Formula: C25H24N6O2<br></br>Solubility: DMSO (>25 mg/ml)<br></br>Physical Properties: White or off-white solid<br></br>Purity: 99% by HPLC NMR (Conforms)
Size: 50mg,10mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.