bs-83411C

DATASHEET

Formulation white or off-white solid

Storage: -20°C

Product Information:

Ibrutinib (936563-96-1) is a very potent (IC50 = 0.5nM) irreversible inhibitor of Bruton tyrosine kinase (BTK) that blocks activation of the B-cell antigen receptor (BCR).1 Ibrutinib also potently inhibits several other kinases including BLK, BMS, FGR, EGFR, and ITK. It is a clinically useful drug to treat B cell cancers. It inhibits CLL cell migration and survival2,3 and downregulates expression of CD204. It enhanced antitumor immune responses in combination with anti PD-L1 blockade via its inhibition of ITK (IL2-inducible T-cell kinase).5

Description:

CAS Number: 936563-96-1; Chemical Name: BTK inhibitor; Molecular Weight: 440.51; Formula: C25H24N6O2; Solubility: DMSO (>25 mg/ml); Physical Properties: White or off-white solid; Purity: 99% by HPLC NMR (Conforms)

Size: 50mg, 10mg

Applications: Life Science(N/A)

For research use only. Not intended for diagnostic or therapeutic use.