bs-83412C

DATASHEET

Formulation yellow solid

Storage: -20°C

Product Information:

Potent and selective inhibitor of Cdk4, IC50 = 11 nM and Cdk6, IC50 = 16 nM.1 Inhibits phosphorylation of Rb protein and cell cycle progression through G1 in primary 5T33MM cells and sensitized these cells to killing by a proteasome inhibitor (bortezomib) in mouse models.2 Induces autophagy and senescence in AGS gastric cancer cells.3 Clinically useful breast cancer agent.4 Cell cycle inhibitors boost tumor immunogenicity.5

Description:

CAS Number: 571190-30-2; Chemical Name: CDK4/CDK6 inhibitor; Molecular Weight: 447.53; Formula: C24H29N7O2; Solubility: DMSO (2 mg/ml); Physical Properties: Yellow solid; Purity: 99% by HPLC/TLC NMR (Conforms)

Size: 25mg, 5mg

Applications: Life Science(N/A)

For research use only. Not intended for diagnostic or therapeutic use.