bs-83412C
[Life Science]
Palbociclib
www.biossusa.com
support@biossusa.com
800.501.7654 [DOMESTIC]
+1.781.569.5821 [INTERNATIONAL]
support@biossusa.com
800.501.7654 [DOMESTIC]
+1.781.569.5821 [INTERNATIONAL]
DATASHEET
Formulation Yellow solid
Storage: -20°C
Product Information:
Potent and selective inhibitor of Cdk4, IC50 = 11 nM and Cdk6, IC50 = 16 nM.1 Inhibits phosphorylation of Rb protein and cell cycle progression through G1 in primary 5T33MM cells and sensitized these cells to killing by a proteasome inhibitor (bortezomib) in mouse models.2 Induces autophagy and senescence in AGS gastric cancer cells.3 Clinically useful breast cancer agent.4 Cell cycle inhibitors boost tumor immunogenicity.5
Description:
CAS Number: 571190-30-2<br></br>Chemical Name: CDK4/CDK6 inhibitor<br></br>Molecular Weight: 447.53<br></br>Formula: C24H29N7O2<br></br>Solubility: DMSO (2 mg/ml)<br></br>Physical Properties: Yellow solid<br></br>Purity: 99% by HPLC/TLC NMR (Conforms)
Size: 25mg,5mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.