bs-83413C [Life Science]
BMS-309403
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Formulation Off-white or pale yellow solid

Storage: -20°C

Product Information:

BMS-309403 is a potent (Ki <2 nM FABP4, Ki = 250 nM FABP3, Ki = 350 nM FABP5) and selective inhibitor of the fatty-acid-binding protein aP2 (FABP4).1,2 It demonstrated marked reductions in atherosclerotic lesions in an Apoe-/- mouse model and improved glucose metabolism, reduced inflammation, and increased insulin sensitivity in a Lepob/ob mouse model. BMS-309403 stimulated glucose uptake in myotubes via activation of AMPK.3 It decreased ER stress-associated inflammation in skeletal muscle4 and suppressed inflammation and oxidative stress in mouse and cell models of acute lung injury5.

Description:

CAS Number: 300657-03-8<br></br>Chemical Name: FABP4 inhibitor<br></br>Molecular Weight: 474.55<br></br>Formula: C31H26N2O3 <br></br>Solubility: DMSO (>25 mg/ml)<br></br>Physical Properties: Off-white or pale yellow solid<br></br>Purity: 98% by HPLC NMR (Conforms)

Size: 25mg,5mg

Applications: Life Science()

For research use only. Not intended for diagnostic or therapeutic use.