bs-83414C

DATASHEET

Formulation yellow solid

Storage: -20°C

Product Information:

AZD1208 is a highly selective and potent pan-PIM kinase inhibitor (IC50 = 3 nM PIM1; 150 nM PIM2; 9 nM PIM3).1 Displayed efficacy in models of acute myeloid leukemia2, prostate cancer3, and triple-negative breast cancer4. Combination treatment of AZD1208 and imatinib eliminated chronic myelogenous leukemia stem cells in cell culture and a patient-derived mouse xenograft model.5 It improved immunotherapeutic antitumor T-cell response6 and disrupted the myeloid cell-mediated immunosuppressive tumor microenvironment increasing T-cell-mediated antitumor immunity.

Description:

CAS Number: 1204144-28-4; Chemical Name: pan-PIM kinase inhibitor; Molecular Weight: 379.48; Formula: C21H21N3O2S; Solubility: DMSO (2 mg/mL with warming); Physical Properties: Yellow solid; Purity: 98% by HPLC NMR (Conforms)

Size: 25mg, 5mg

Applications: Life Science(N/A)

For research use only. Not intended for diagnostic or therapeutic use.