bs-83416C

DATASHEET

Formulation Off-white solid

Storage: -20°C

Product Information:

Abemaciclib (1231930-82-7) is a potent and selective CDK4/6 inhibitor (IC50 = 2 nM and 10 nM respectively).1 It caused G1 cell cycle arrest in colo-205 colorectal cells, MDA-MB-361 breast cancer cells, and MV4-11 AML cells. Abemaciclib was also active in several human tumor xenograft models. It displayed efficacy in patients with various solid tumors including breast cancer, non-small cell lung cancer, glioblastoma, melanoma, colorectal cancer, and hormone receptor-positive breast cancer.2 Abemaciclib induced a T cell inflamed tumor microenvironment and enhanced the efficacy of PD-L1 checkpoint blockade in MCF-7 breast cancer cells.3 FDA approved for the treatment of advanced breast cancers.

Description:

CAS Number: 1231930-82-7 Chemical Name: CDK 4/6 inhibitor Molecular Weight: 602.70 Formula: C27H32F2N8·CH3SO3H Solubility: DMSO > 25 mg/ml Water > 25 mg/ml Physical Properties: Off-white solid Purity: >98% by HPLC NMR (Conforms)