bs-83417C [Life Science]
LY2090314
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Formulation Orange solid

Storage: -20°C

Product Information:

Wnt/ß-catenin pathway activator. LY2090314 is a highly potent (IC50 = 1.5 nM GSK-3α; 0.9 nM GSK-3ß) and selective inhibitor of glycogen synthase-3-kinase (GSK-3).1,2 It stabilized ß-catenin levels and elevated expression of Axin2 leading to tumor growth delays in A375 melanoma xenografts.2 LY2090314 significantly reduced growth in multiple neuroblastoma cell lines.3 It inhibited growth and induced apoptosis in osimertinib-resistant lung cancer cells, specifically those with a mesenchymal phenotype.4

Description:

CAS Number: 603288-22-8<br></br>Chemical Name: Wnt/ß-Catenin pathway activator / GSK-3 inhibitor<br></br>Molecular Weight: 512.54<br></br>Formula: C28H25FN6O3<br></br>Solubility: DMSO (>20 mg/ml)<br></br>Physical Properties: Orange solid<br></br>Purity: >98% by HPLC NMR (Conforms)

Size: 25mg,5mg

Applications: Life Science()

For research use only. Not intended for diagnostic or therapeutic use.