bs-83419C [Life Science]
UH15-38·2HCl
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Formulation Yellow solid

Storage: -20°C

Product Information:

UH15-38 is a potent (IC50 = 20 nM) inhibitor of RIPK3 with excellent cellular activity. It blocked TNF-induced necroptosis in primary mouse embryonic fibroblasts (IC50 = 98 nM). UH15-38 selectively blocked influenza A-induced necroptosis over apoptosis in mouse alveolar epithelial cells, mouse embryonic fibroblasts, and human M29 cells at nanomolar levels. It attenuated influenza A-induced lung injury and lethality in vivo.

Description:

CAS Number: 2540881-21-6 (free base)<br></br>Chemical Name: RIP3K inhibitor<br></br>Molecular Weight: 514.45<br></br>Formula: C26H27N5O·2HCl<br></br>Solubility: DMSO (5 mg/ml) Water (>20 mg/ml)<br></br>Physical Properties: Yellow solid<br></br>Purity: >98% by HPLC NMR (Conforms)

Size: 25mg,5mg

Applications: Life Science()

For research use only. Not intended for diagnostic or therapeutic use.