bs-83419C

DATASHEET

Formulation yellow solid

Storage: -20°C

Product Information:

UH15-38 is a potent (IC50 = 20 nM) inhibitor of RIPK3 with excellent cellular activity. It blocked TNF-induced necroptosis in primary mouse embryonic fibroblasts (IC50 = 98 nM). UH15-38 selectively blocked influenza A-induced necroptosis over apoptosis in mouse alveolar epithelial cells, mouse embryonic fibroblasts, and human M29 cells at nanomolar levels. It attenuated influenza A-induced lung injury and lethality in vivo.

Description:

CAS Number: 2540881-21-6 (free base); Chemical Name: RIP3K inhibitor; Molecular Weight: 514.45; Formula: C26H27N5O·2HCl; Solubility: DMSO (5 mg/ml) Water (>20 mg/ml); Physical Properties: Yellow solid; Purity: >98% by HPLC NMR (Conforms)

Size: 25mg, 5mg

Applications: Life Science(N/A)

For research use only. Not intended for diagnostic or therapeutic use.