bs-83423C [Life Science]
Osimertinib
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Formulation Pale-yellow solid

Storage: -20°C

Product Information:

Osimertinib is a potent, selective, irreversible inhibitor of mutant EFGR tyrosine kinase.1 Osimertinib inhibits phosphorylation of EGFR in T790M-mutant cell lines (IC50 <15 nM) but was less potent at inhibition of EGFR phosphorylation in wild-type cells (IC50s in the range of 480 to 1,865 nM). It produces sustained tumor regression in EGFR-mutant tumor xenograft and transgenic rodent models.2 Tumor cells develop resistance to osimertinib but combination treatment with an IL-6 antibody reverses resistance to a certain extent.3 In clinical use for treatment of non-small cell lung cancer.4

Description:

CAS Number: 1421373-65-0<br></br>Chemical Name: Mutant EGFR kinase inhibitor<br></br>Molecular Weight: 499.62<br></br>Formula: C28H33N7O2<br></br>Solubility: DMSO (40 mg/ml)<br></br>Physical Properties: Pale-yellow solid<br></br>Purity: >98% by HPLC NMR (Conforms)

Size: 50mg,10mg

Applications: Life Science()

For research use only. Not intended for diagnostic or therapeutic use.