bs-83423C

DATASHEET

Formulation Pale-yellow solid

Storage: -20°C

Product Information:

Osimertinib is a potent, selective, irreversible inhibitor of mutant EFGR tyrosine kinase.1 Osimertinib inhibits phosphorylation of EGFR in T790M-mutant cell lines (IC50 <15 nM) but was less potent at inhibition of EGFR phosphorylation in wild-type cells (IC50s in the range of 480 to 1,865 nM). It produces sustained tumor regression in EGFR-mutant tumor xenograft and transgenic rodent models.2 Tumor cells develop resistance to osimertinib but combination treatment with an IL-6 antibody reverses resistance to a certain extent.3 In clinical use for treatment of non-small cell lung cancer.4

Description:

CAS Number: 1421373-65-0; Chemical Name: Mutant EGFR kinase inhibitor; Molecular Weight: 499.62; Formula: C28H33N7O2; Solubility: DMSO (40 mg/ml); Physical Properties: Pale-yellow solid; Purity: >98% by HPLC NMR (Conforms)

Size: 50mg, 10mg

Applications: Life Science(N/A)

For research use only. Not intended for diagnostic or therapeutic use.