bs-83425C

DATASHEET

Formulation Off-White solid

Storage: -20°C

Product Information:

ICRF-193 is a topoisomerase II poison.1 Toposiomerase poisons are a special subclass of topoisomerase inhibitors that stabilize topoisomerase-DNA strand passing intermediates and thus cause the topoisomerases to become a cytotoxic DNA-damaging agent.1 It readily induces DNA strand breaks in V79 and irs-2 Chinese hamster lung fibroblasts via a novel mechanism.2 Displays cardioprotective (against anthracycline toxicity)3 and anti-inflammatory effects via reduction of IL-1β secretion by macrophages4. An important tool for studying the cellular response to DNA double-strand breaks.5

Description:

CAS Number: 21416-88-6; Chemical Name: Topoisomerase II inhibitor; Molecular Weight: 282.3; Formula: C12H18N4O4; Solubility: DMSO (4 mg/ml); Physical Properties: Off-white solid; Purity: >98% by TLC NMR (Conforms)

Size: 5mg, 1mg

Applications: Life Science(N/A)

For research use only. Not intended for diagnostic or therapeutic use.