bs-83426C [Life Science]
Ponatinib
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Formulation Yellow solid

Storage: -20°C

Product Information:

Highly potent pan-Bcr-Abl and multikinase inhibitor, suppressing the activity of native Bcr-Abl (IC50=0.37 nM) as well as the mutants T315I (IC50=2 nM), Q252H (IC50=0.44 nM), Y253F (IC50=0.3 nM), M351T (IC50=0.3 nM) and H396P (IC50=0.34 nM).1 Also inhibits PDGFR, c-Src and c-Kit (IC50=1.1, 5.4 and 12.5 nM respectively)2 as well as FGFR-mediated signaling (IC50<40 nM)3. Protects against influenza A virus-induced death by suppressing cytokine storm in mouse models.4

Description:

CAS Number: 943319-70-8<br></br>Chemical Name: Bcr-Abl and multikinase inhibitor<br></br>Molecular Weight: 532.56<br></br>Formula: C29H27F3N6O<br></br>Solubility: DMSO (50 mg/ml) Ethanol (25 mg/ml)<br></br>Physical Properties: Yellow solid<br></br>Purity: 98% by HPLC NMR (Conforms)

Size: 25mg,5mg

Applications: Life Science()

For research use only. Not intended for diagnostic or therapeutic use.