bs-83430C [Life Science]
PLX4720
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Formulation White solid

Storage: -20°C

Product Information:

Potent and selective inhibitor of B-Raf, V600E mutant, IC50=13 nM (Wild type IC50=160 nM).1 It induces cell cycle arrest and apoptosis in B-RafV600E-positive cells and suppresses growth of B-RafV600E-positive xenografts.1 It induces tumor regression and reverses cachexia in a mouse model of human thyroid cancer harboring the B-RafV600E mutation.2 Early stage autophagy inhibitors and ER stress inhibition with 4-phenylbutyric acid increases the sensitivity of resistant cells to PLX4720.3 PLX4720 induces cytoprotective autophagy in thyroid cancer cells via AMPK-ULK1 pathway.4

Description:

CAS Number: 918505-84-7<br></br>Chemical Name: Mutant B-Raf inhibitor<br></br>Molecular Weight: 413.82<br></br>Formula: C17H14ClF2N3O3S<br></br>Solubility: DMSO (55 mg/ml with warming)<br></br>Physical Properties: White solid<br></br>Purity: >98% by HPLC NMR (Conforms)

Size: 25mg,5mg

Applications: Life Science()

For research use only. Not intended for diagnostic or therapeutic use.