bs-83435C
[Life Science]
Tepotinib
DATASHEET
Formulation White solid
Storage: -20°C
Product Information:
Tepotinib is a selective type 1b MET inhibitor. In biochemical assays using His6-tagged recombinant human MET kinase domain, tepotinib inhibited kinase activity in a concentration-dependent manner with IC50=1.8 nM.1 It displays marked antitumor activity in MET-dependent tumor models.2 It crosses the blood-brain barrier and displays intracranial antitumor activity.3 Tepotinib can overcome EGFR inhibitor resistance mediated by aberrant c-Met activation4 and is in clinical use for non-small cell lung cancer harboring MET exon 14 skipping alterations.
Description:
CAS Number: 1100598-32-0<br></br>Chemical Name: c-Met inhibitor<br></br>Molecular Weight: 492.58<br></br>Formula: C29H28N6O2<br></br>Solubility: DMSO (17 mg/ml with warming)<br></br>Physical Properties: White solid<br></br>Purity: >98% by TLC NMR (Conforms)
Size: 25mg,5mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.