bs-83436C
[Life Science]
MLS-544460
DATASHEET
Formulation Cream/off-white solid
Storage: -20°C
Product Information:
MLS-544460 is an allosteric inhibitor of the Eya2 tyrosine phosphatase (IC50=4.1 uM)1-2 which is ineffective against other tyrosine phosphatases including Eya3 and PTP1B. Treatment of patient-derived glioma stem cells induced loss of bipolar spindle formation along with G2/M cell cycle arrest. GSC proliferation was inhibited at concentrations 4 to 10-fold lower than normal brain cells.3 Treatment of Axolotls following amputation impairs limb regeneration indicating a role for Eya2 in vertebrate regeneration.4
Description:
CAS Number: 352336-36-8<br></br>Chemical Name: Eya2 phosphatase inhibitor<br></br>Molecular Weight: 341.36<br></br>Formula: C17H12FN3O2S<br></br>Solubility: DMSO (40 mg/ml)<br></br>Physical Properties: Cream/off-white solid<br></br>Purity: >98% by TLC NMR (Conforms)
Size: 25mg,5mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.