bs-83439C

DATASHEET

Formulation White to off-white solid

Storage: -20°C

Product Information:

Potent and selective allosteric1 inhibitor of kidney-type glutaminase (GLS1), IC50 = 3.3 µM2. Selective for GLS1 over GLS2, g-glutamyl transpeptidase and glutamate dehydrogenase. Shuts down an alternative energy-generating glutaminolysis pathway in P493 cells under both glucose deprivation or hypoxia.3 Reduces the growth of P493 cell xenografts by 50% over a 10 day treatment.4 BPTES inhibition of glutamine utilization in cancer cells increases PD-L1 expression.5 Clears senescent cells and improves various age-related disorders in a geriatric mouse model.6

Description:

CAS Number: 314045-39-1; Chemical Name: Glutaminase GLS1 inhibitor; Molecular Weight: 524.68; Formula: C24H24N6O2S3; Solubility: DMSO (10 mg/ml); Physical Properties: White to off-white solid; Purity: 98% by TLC, NMR (Conforms)

Size: 25mg, 5mg

Applications: Life Science(N/A)

For research use only. Not intended for diagnostic or therapeutic use.