bs-83442C
[Life Science]
TPCA-1
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support@biossusa.com
800.501.7654 [DOMESTIC]
+1.781.569.5821 [INTERNATIONAL]
DATASHEET
Formulation Pale yellow solid
Storage: -20°C
Product Information:
Selective inhibitor of IκB kinase 2 (IKK2) (IC50 = 17.9 nM).1 Inhibits production of pro-inflammatory cytokines in arthritis and other animal models of inflammation.1,2 Also attenuates NLRP3 inflammasome activation in THP-1 myeloid cells, and suppresses IL1β-induced proliferation, migration, and invasion of HeLa cells.3,4 Continuous exposure to TPCA-1 promotes expansion of hematopoietic stem/progenitor cells (HSPCs) via improved glycolysis and limited ROS production.5
Description:
CAS Number: 507475-17-4<br></br>Chemical Name: Selective inhibitor of IκB kinase 2 (IKK2)<br></br>Molecular Weight: 229.29<br></br>Formula: C12H10FN3O4S<br></br>Solubility: DMSO (30 mg/ml)<br></br>Physical Properties: Pale yellow solid<br></br>Purity: 98% by TLC NMR (Conforms)
Size: 25mg,5mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.