bs-83443C

DATASHEET

Formulation White Solid

Storage: -20°C

Product Information:

L6H21 binds to MD-2 (myeloid differentiation protein-2, Kd=33.3 µM) and blocks its interaction with TLR4 (toll-like receptor 4) in LPS-stimulated cells, inhibiting TNFα and IL-6 production.1 Attenuates disease progression in a high-fat diet (HFD) induced NASH mouse model.2 Inhibits obesity-induced cardiomyopathy and fibrosis.3 Reduces ethanol plus LPS-induced liver injury via inhibition of NLRP3 inflammasome activation.4 Provides cardioprotective effects5 and protects against cognitive impairment and brain pathologies in HFD prediabetic rats6. Cell permeable. Active in vivo.

Description:

CAS Number: 24533-47-9; Chemical Name: MDL/TLR4 interaction inhibitor; Molecular Weight: 298.34; Formula: C18H18O4; Solubility: DMSO (60 mg/ml); Physical Properties: White solid; Purity: 98% by HPLC NMR (Conforms)

Size: 25mg, 5mg

Applications: Life Science(N/A)

For research use only. Not intended for diagnostic or therapeutic use.