bs-83450C

DATASHEET

Formulation beige solid

Storage: -20°C

Product Information:

Potent and selective HDAC3 inhibitor (IC50 = 289 nM), IC50s for HDAC1, 2 and 6 = 2, 2.2 and >20 mM respectively.1 Inhibits tumor growth in a mouse xenograft model of human multiple myeloma.1 Downregulates expression of DNA methyltransferase 1.2 Increases expression of synaptic proteins in exogenous Aβ-treated cells and mice.3 Rescues synaptic damage and neuron loss in APP-transfected cells (15 mM) and APP/PS1 mice (30 mg/kg).4

Description:

CAS Number: 926259-99-6; Chemical Name: HDAC3 selective inhibitor; Molecular Weight: 214.23; Formula: C11H10N4O; Solubility: DMSO (45 mg/ml); Physical Properties: Beige solid; Purity: >98% by HPLC NMR (Conforms)

Size: 25mg, 5mg

Applications: Life Science(N/A)

For research use only. Not intended for diagnostic or therapeutic use.