bs-83454C
[Life Science]
TTK21
DATASHEET
Formulation Off-white solid
Storage: -20°C
Product Information:
TTK21 (709676-56-2) is a novel activator of CBP/p300 acetyl transferases.1 When TTK21 is conjugated to glucose-based carbon nanospheres (CSP) it is nontoxic and is BBB permeable. CSP-TTK21, upon intraperitoneal administration to mice, acetylated histones in the hippocampus and frontal cortex and increased BDNF levels.1 It reinstated plasticity and memory in a tauopathy mouse model2, ameliorated Aβ-impaired long term potentiation3 and promoted axon growth, sprouting and synaptic plasticity in chronic experimental spinal cord injury4.
Description:
CAS Number: 709676-56-2<br></br>Chemical Name: CBP/p300 histone acetyltransferase activator<br></br>Molecular Weight: 357.76<br></br>Formula: C17H15ClF3NO2<br></br>Solubility: DMSO (50 mg/ml)<br></br>Physical Properties: Off-white solid<br></br>Purity: >98% by HPLC NMR (Conforms)
Size: 25mg,5mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.