bs-83455C
[Life Science]
BMH-21
DATASHEET
Formulation Orange solid
Storage: -20°C
Product Information:
A planar heterocyclic DNA intercalator that inhibits RNA polymerase I (Pol I), IC50 = 0.6 µM in U2OS cells, but not Pols II or III, blocking transcription elongation without inducing the DNA damage response.1-3 Inhibition disengages Pol I from chromatin, resulting in proteasome-dependent destruction of Pol I subunit RPA194.4 At nanomolar concentrations it also activates p53 in A375 cells.5
Description:
CAS Number: 896705-16-1<br></br>Chemical Name: RNA polymerase I inhibitor<br></br>Molecular Weight: 360.42<br></br>Formula: C21H20N4O2<br></br>Solubility: DMSO (13 mg/ml with warming)<br></br>Physical Properties: Orange solid<br></br>Purity: >98% by HPLC NMR (Conforms)
Size: 25mg,5mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.