bs-83455C

DATASHEET

Formulation Orange solid

Storage: -20°C

Product Information:

A planar heterocyclic DNA intercalator that inhibits RNA polymerase I (Pol I), IC50 = 0.6 µM in U2OS cells, but not Pols II or III, blocking transcription elongation without inducing the DNA damage response.1-3 Inhibition disengages Pol I from chromatin, resulting in proteasome-dependent destruction of Pol I subunit RPA194.4 At nanomolar concentrations it also activates p53 in A375 cells.5

Description:

CAS Number: 896705-16-1; Chemical Name: RNA polymerase I inhibitor; Molecular Weight: 360.42; Formula: C21H20N4O2; Solubility: DMSO (13 mg/ml with warming); Physical Properties: Orange solid; Purity: >98% by HPLC NMR (Conforms)

Size: 25mg, 5mg

Applications: Life Science(N/A)

For research use only. Not intended for diagnostic or therapeutic use.