bs-83457C
[Life Science]
SU9516
DATASHEET
Formulation Orange solid
Storage: -20°C
Product Information:
Cyclin-dependent kinase inhibitor, IC50s= 0.02-0.03, 0.04-0.2, 0.2-1.7 and 0.9 µM for cdk2, cdk1, cdk4, cdk9 respectively.1,2 Inhibits phosphorylation of retinoblastoma protein pRb, causing enhanced pRb/E2f complex formation, cell cycle arrest at G1 and G2-M and apoptosis.3 Down-regulates antiapoptotic protein Mcl-1 expression resulting in mitochondrial injury and cell death.4 Inhibits epithelial-mesenchymal transition (IC50=1.21 µM) a crucial pathological event in tumor cell budding and metastasis.5 Cell permeable.
Description:
CAS Number: 377090-84-1<br></br>Chemical Name: CDK inhibitor (pan-specific)<br></br>Molecular Weight: 241.25<br></br>Formula: C13H11N3O2<br></br>Solubility: DMSO (25 mg/ml)<br></br>Physical Properties: Orange solid<br></br>Purity: >98% by HPLC NMR (Conforms)
Size: 25mg,5mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.