bs-83711C [Life Science]
ARV-110
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Formulation Pale yellow solid

Storage: -20°C

Product Information:

ARV-110 is a CRBN-based PROTAC protein degrader that recruits the cereblon-containing E3 ubiquitin ligase to direct the proteasomal degradation of the androgen receptor (AR). It selectively degrades wild-type AR and most clinically relevant mutants with low nM potency.1 ARV-110 is the first PROTAC to enter the clinic.2 Analytical methods suitable for pharmacokinetic studies have been developed.3

Description:

CAS Number: 2222112-77-6<br></br>Chemical Name: N-[trans-4-(3-Chloro-4-cyanophenoxy)cyclohexyl]-6-[4-[[4-[2-(2,6-dioxo-3-piperidinyl)-6-fluoro-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]-1-piperazinyl]methyl]-1-piperidinyl]-3-pyridazinecarboxamide<br></br>Molecular Weight: 812.3<br></br>Formula: C41H43ClFN9O6<br></br>Solubility: DMSO (25 mg/ml)<br></br>Physical Properties: Pale yellow solid<br></br>Purity: 98% by HPLC NMR (Conforms)

Applications: Life Science

For research use only. Not intended for diagnostic or therapeutic use.