bs-83740C
[Life Science]
PF-06835919
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support@biossusa.com
800.501.7654 [DOMESTIC]
+1.781.569.5821 [INTERNATIONAL]
DATASHEET
Formulation White solid
Storage: -20°C
Product Information:
PF-06835919 is a potent (IC50 = 10 nM KHK-C; 170 nM KHK-A) inhibitor of ketohexokinase (KHK), the first enzyme in the fructose metabolic cascade.1 It displayed high selectivity against other sugar kinases. PF-06835919 prevented hyperinsulinemia, hypertriglyceridemia, and hepatic steatosis in fructose-fed rats.2 The increased tumor proliferation effect of fructose in CaSki cells was inhibited by PF-06835919.3 An interesting new tool to study metabolic and fatty liver diseases.
Description:
CAS Number: 2102501-84-6<br></br>Chemical Name: 2-[(1R,5S)-3-[2-[(2S)-2-methylazetidin-1-yl]-6-(trifluoromethyl)pyrimidin-4-yl]-3-azabicyclo[3.1.0]hexan-6-yl]acetic acid<br></br>Molecular Weight: 356.35<br></br>Formula: C16H19F3N4O2<br></br>Solubility: DMSO (10 mg/ml with warming)<br></br>Physical Properties: White solid<br></br>Purity: >98% by HPLC, NMR (conforms)
Size: 1mg,5mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.