bs-83758C
[Life Science]
Idasanutlin
www.biossusa.com
support@biossusa.com
800.501.7654 [DOMESTIC]
+1.781.569.5821 [INTERNATIONAL]
support@biossusa.com
800.501.7654 [DOMESTIC]
+1.781.569.5821 [INTERNATIONAL]
DATASHEET
Formulation White solid
Storage: -20°C
Product Information:
Idasanutlin is a potent (IC50 = 6 nM) and selective inhibitor of MDM2, the primary negative regulator of p53.1 It blocks the p53-MDM2 interaction activating the p53 pathway leading to cell cycle arrest and apoptosis. Idasanutlin has displayed efficacy in the treatment of multiple cancers alone and in combination with other chemotherapeutics.2-6
Description:
CAS Number: 1229705-06-9<br></br>Chemical Name: 4-[[(2R,3S,4R,5S)-3-(3-Chloro-2-fluorophenyl)-4-(4-chloro-2-fluorophenyl)-4-cyano-5-(2,2-dimethylpropyl)pyrrolidine-2-carbonyl]amino]-3-methoxybenzoic acid<br></br>Molecular Weight: 616.49<br></br>Formula: C31H29Cl2F2N3O4<br></br>Solubility: DMSO (>25 mg/ml) <br></br>Physical Properties: White solid<br></br>Purity: >98% by HPLC NMR (Conforms)
Size: 5mg, 25mg
Applications: Life Science
For research use only. Not intended for diagnostic or therapeutic use.