bs-83761C
[Life Science]
VER-246608
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800.501.7654 [DOMESTIC]
+1.781.569.5821 [INTERNATIONAL]
support@biossusa.com
800.501.7654 [DOMESTIC]
+1.781.569.5821 [INTERNATIONAL]
DATASHEET
Formulation White to off-white solid
Storage: -20°C
Product Information:
VER-246608 is a potent (IC50’s: PDK-1 = 35 nM, PDK-2 = 84 nM, PDK-3 = 40 nM, PDK-4 = 91 nM) and selective pan-pyruvate dehydrogenase kinase inhibitor.1 It decreased oxygen consumption and attenuated glycolytic activity (Warburg metabolism) under D-glucose/L-glutamine-depleted conditions. VER-246608 treatment of four cancer lines (PC-3, SW-1088, UM-22B, and MEF) under depleted D-glucose/L-glutamine conditions resulted in almost complete inhibition of cell growth. It also acted synergistically with doxorubicin in PC-3 and ES-2 cells.
Description:
CAS Number: 1684386-71-7<br></br>Chemical Name: N-[4-(2-chloro-5-methylpyrimidin-4-yl)phenyl]-N-[[4-[[(2,2-difluoroacetyl)amino]methyl]phenyl]methyl]-2,4-dihydroxybenzamide<br></br>Molecular Weight: 552.96<br></br>Formula: C28H23ClF2N4O4<br></br>Solubility: DMSO (>25 mg/ml)<br></br>Physical Properties: White to off-white solid<br></br>Purity: >98% by HPLC NMR (Conforms)
Size: 5mg, 25mg
Applications: Life Science
For research use only. Not intended for diagnostic or therapeutic use.