bs-83766C [Life Science]
(R)-GNE-140
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Formulation Off-white to pale orange solid

Storage: -20°C

Product Information:

(R)-GNE-140 is a potent (IC50’s: LDHA = 3 nM, LDHB = 5 nM, LDHC = 5 nM) pan-lactate dehydrogenase inhibitor.1 It significantly decreased lactate levels in vivo, although the effects were transient. GNE-140 suppressed lactic acid production, severely stunted glucose utilization, and impeded the anaerobic glycolytic pathway in MDA-MB-231 triple negative breast cancer cells.2

Description:

CAS Number: 2003234-63-5<br></br>Chemical Name: (2R)-5-(2-Chlorophenyl)sulfanyl-4-hydroxy-2-(4-morpholin-4-ylphenyl)-2-thiophen-3-yl-1,3-dihydropyridin-6-one<br></br>Molecular Weight: 499.04<br></br>Formula: C25H23ClN3O3S2<br></br>Solubility: DMSO (>25 mg/ml)<br></br>Physical Properties: Off-white to pale orange solid<br></br>Purity: >98% by HPLC NMR (Conforms)

Size: 5mg, 25mg

Applications: Life Science

For research use only. Not intended for diagnostic or therapeutic use.