bs-83768C

DATASHEET

Formulation Off-white solid

Storage: -20°C

Product Information:

SPHINX31 is a potent (IC50 = 5.9 nM) and selective inhibitor of serine/arginine-rich protein kinase 1 (SRPK1), a splice factor kinase involved in VEGF-A isoform formation and other alternative splicing events.1 It displayed antiangiogenic effects in a mouse model of choroidal neovascularization1 a rat model of diabetic retinopathy2. SPHINX31 exhibited antitumor and synergistic (with cisplatin) effects in extranodal lymphoma cells.3 It was able to change splicing of programmed cell death receptor 1 (PD-1) to produce a more soluble form that prevented T cell exhaustion in a cancer model.4 It corrected BIN1, MCL-1, and BCL2 splicing errors in cholangiocarcinoma cells resulting in apoptosis of cancer cells.5

Description:

CAS Number: 1818389-84-2 Chemical Name: 5-Pyridin-4-yl-N-[2-[4-(pyridin-2-ylmethyl)piperazin-1-yl]-5-(trifluoromethyl)phenyl]furan-2-carboxamide Molecular Weight: 507.52 Formula: C27H24F3N5O2 Solubility: DMSO (15 mg/ml with warming) Physical Properties: Off-white solid Purity: >98% by HPLC NMR (Conforms)